Everything about Cyp2a6 totally explained
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| Name = Cytochrome P450, family 2, subfamily A, polypeptide 6
| HGNCid = 2610
| Symbol = CYP2A6
| AltSymbols =; CYP2A; P450C2A; P450PB; CPA6; CYP2A3; CPA7; CPAD; CYPIIA7; P450-IIA4
| OMIM = 122720
| ECnumber =
| Homologene = 86656
| MGIid =
| Function =
| Component =
| Process =
| Orthologs =
}}
Cytochrome P450 2A6 (abbreviated
CYP2A6) is a member of the
cytochrome P450 mixed-function oxidase system, which is involved in the metabolism of
xenobiotics in the body. CYP2A6 is the primary enzyme responsible for the oxidation of
nicotine and
cotinine. It is also involved in the metabolism of several pharmaceuticals, carcinogens, and a number of coumarin-type alkaloids. CYP2A6 is the only enzyme in the human body that appreciably catalyzes the 7-hydroxylation of
coumarin, such that the formation of the product of this reaction, 7-hydroxycoumarin, is used as a probe for CYP2A6 activity.
The CYP2A6 gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6.
Distribution
CYP2A6 localizes to the
endoplasmic reticulum and is found predominantly in the liver.
Variability
Significant interindividual variability in CYP2A6 apoprotein and mRNA levels has been observed.
Induction
CYP2A6 is known to be
inducible by
phenobarbital and
rifampicin, and it's suspected that other antiepileptic drugs may also have this effect.
CYP2A6 Ligands
Further Information
Get more info on 'Cyp2a6'.
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